Abstract
Summary
Rats were treated with norethynodrel with mestranol given orally mixed with their diet in amounts calculated to give 1 and 10 × the normal human amount on a weight basis. The animals which received 10 × normal norethynodrel-mestranol had a significant decrease in their blood pressure response to the largest amount of angiotensin and a significant increase in their blood pressure response to renin. These data indicate that renin substrate is rate-limiting in vivo.
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