Effect of Dopamine on the Biological Activity and in Vitro Release of ACTH and FSH 1

Abstract

Summary

Pituitary tissue and rat pituitary extracts were incubated with dopamine in vitro. The results indicate that dopamine chemically inactivates ACTH and FSH when incubated in high concentration with these hormones for prolonged periods. The data fail to support a direct effect of dopamine on the pituitary release of ACTH and FSH, and dopamine does not alter the pituitary response to hypothalamic extract.