Abstract
Summary
The ability of angiotensin to cause release of catecholamines from adrenergic nerve endings was studied in anesthetized dogs in which the femoral vascular bed was perfused at constant flow and in which reflexly induced changes in perfusion pressure were abolished by epidural blockade. Magnitude and rate of development of the pressor response to angiotensin were examined prior to blockade and after alpha adrenergic blockade with phenoxybenzamine or beta adrenergic blockade with propranolol. No significant alterations in the pressor response were observed following adrenergic receptor blockade. As no evidence was obtained for release of catecholamines by angiotensin in this preparation, any effects of angiotensin on reuptake of catecholamines would not be tested.
The author thanks Dr. W. B. Youmans for his continued encouragement and for his many helpful suggestions during the preparation of this manuscript.
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