Abstract
Summary
Aqueous extract of rat aorta wall (NAE) induces gradual and sustained elevation of systolic and diastolic blood pressure in rats made hypotensive by inhibitors of protein synthesis, actinomycin D and acetoxycycloheximide. The pressor response is obtained only from extracts of arterial and not other smooth or striated muscle tissue. NAE has no significant effect on normal or other hypotensive rats. It apparently replaces a specific deficiency of a vasoactive factor induced by these antimetabolites. This factor differs physiologically from other pressor agents by acting apparently on arterial tone rather than phasic contractility. Preliminary data suggest it may be a polypeptide.
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