Strontium Inhibition of Vitamin D 3 -Induced Calcium-Binding Protein (CaBP) and Calcium Absorption in Chick Intestine 1

Abstract

Summary

Supplementation of a low calcium, vitamin D₃-replete diet with strontium, to the extent of the molar equivalent of 1.2% calcium, induced rickets and completely inhibited CaBP production and intestinal calcium absorption after only 1 week of feeding to previously normal chicks. These observations suggest that strontium-induced rickets may be the result of interference with the calcium absorptive mechanism.