Abstract
Summary
Our results indicate that isolated adipose cells from older mice convert glucose to carbon dioxide as rapidly as cells from young mice. Therefore, a slowed basal glucose conversion rate in isolated cell preparations is not exclusively age-related, but depends on the number of cells in the aliquot. Our data do not substantiate an age difference in rate of glucose conversion to CO2 per cell by adipocytes in C57B mice. Decreased insulin response in adipocytes may represent cell size changes rather than direct age-related changes.
The authors wish to express their deep appreciation to Dr. Anita Zorzoli at Vassar College for providing the mice for this study. We also wish to thank Mrs. Kirsten Glasser and Miss Florence Oetjen for their excellent technical assistance.
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