Abstract
Summary
17β-Estradiol, growth hormone, and insulin were administered to ovariectomized (Ox), diabetic-ovariectomized (DOx) and hypophysectomized–ovariectomized (HxOx) rats to observe their effects on the incorporation of tritiated uridine into the uterine RNA and acid-soluble fraction. Insulin administered to DOx rats stimulated the incorporation of tritiated uridine into uterine RNA and the acid-soluble fraction within 15 min. The stimulatory effects were potentiated with the combined administration of insulin and 17β-estradiol. The administration of growth hormone to HxOx rats resulted in an increase in the incorporation of labeled uridine into uterine RNA and acid-soluble fraction. The combined administration of 17β-estradiol and growth hormone caused a slight increase in the incorporation of uridine into uterine RNA which was less than additive and a decrease in the incorporation into the acid-soluble fraction. The results of the present study suggest that insulin and growth hormone in addition to 17β-estradiol influence uterine RNA synthesis.
We express our appreciation to Dr. Sheldon J. Segal for his interest, support and encouragement which facilitated this study. The technical assistance of Miss C. Avila is gratefully acknowledged.
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