Abstract
Summary
Intraperitoneally administered chlorpromazine produced a dose-related increase in blood glucose levels in the mouse. The magnitude of the hyperglycemic response is related to liver glycogen levels, since fasting depleted liver glycogen and attenuated the hyperglycemic response. Mice quickly develop tolerance to the hyperglycemic effect of CPZ and 18 hr after a single dose of chlorpromazine a second dose of the drug is not hyperglycemic. Tolerance to chlorpromazine-induced hyperglycemia does not impart tolerance to the hyperglycemic effects of either epinephrine or alloxan. Chlorpromazine was also found to reduce glucose tolerance in mice, but the reduced glucose tolerance is not completely antagonized by pretreatment with CPZ.
The authors thank Mrs. Judith Stilwell for providing excellent technical assistance.
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