Effects of Compounds which Inhibit Antigenic Release of Histamine and Phagocytic Release of Lysosomal Enzyme on Glucose Utilization by Leukocytes in Humans 1

Abstract

Summary

Antigenic release of histamine from leukocytes of hypersensitive persons is not accompanied by release of the lysosomal enzyme, β-glucuronidase. Likewise, histamine is not released during phagocytic release of β-glucuronidase. Both processes are inhibited by dibutyryl cyclic 3′, 5′-adenosine monophosphate, theophylline, nicotinamide, and ethanol. These four compounds were found to also suppress utilization of glucose by leukocytes from humans, the concentrations and rank order of potency required being the same magnitude as inhibited release of histamine. Considerations pertinent to determination of mechanisms which could account for the effects of these compounds are discussed.

The skillful and diligent technical assistance of Misses Janet Strollo, Bonnie Boilini and Kathryn Krakauer are gratefully acknowledged.