Abstract
Summary
The cellular mechanism of immunologic tolerance in cyclophosphamide-treated mice was analyzed. Thymocytes from these animals failed to act synergistically with normal marrow cells in heavily irradiated recipients. By contrast, the marrow cells of tolerant mice cooperated with normal thymocytes in the X-rayed recipients. Tolerance in the drug-treated mice was broken by administration of thymocytes, but not by marrow cells. It was concluded that the target cell in drug-induced immunologic tolerance is a thymus-dependent lymphocyte.
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