Abstract
Summary
Sodium octanoate, when added in increasing concentrations directly into the reaction mixture, resulted in progressive inhibition of α-glycerophosphate dehydrogenase activity in rat heart and adipose tissue. A complete inhibition of the cardiac and adipose tissue enzyme was produced when the supernatant fluids were preincubated with octanoate (5 mM) for a period of 20 min. It is suggested that the free fatty acids play an important regulatory role in controlling the interconversion of glucose and triglycerides through negative modulation of α-glycerophosphate dehydrogenase.
This investigation was supported in part by grants from the Medical Research Council of Canada, the Upjohn Company and Eli Lilly and Co., Indianapolis, Indiana.
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