Abstract
Summary
Fresh normal rabbit serum was more effective than guinea pig complement in immune cytolytic reactions with inactivated antiviral serum and ascites tumor cells infected with Sendai virus, and also in cytolysis with a mouse histocompatibility antigen and homologous antibody. When the antiviral rabbit serum had not been heated to 56° both guinea pig complement and rabbit complement augmented viral-immune cytolysis. A primary effect of immune cytolysis on the cell membrane was indicated by the appearance in some cells of permeability to dye before respiration was impaired.
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