Abstract
Conclusion
Previously reported values for DNA in continuously propagated cell lines, such as KB, HeLa, and FL, were significantly higher than those for normal cells (13). Our data also show an increase in DNA content for two transformed cell lines with malignant characteristics, both derived from normal amnion cells. However, the similarity in DNA content for FL and F 138cl cells indicates that mycoplasma modification, including the change in the malignant state and a reduction of approximately 15% of the chromosome number, cannot be explained by a loss of DNA, but may be interpreted by a rearrangement of the genetic material.
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