Abstract
Summary
Artificial changes in plasma FFA concentrations were induced in dogs by infusion of nicotinic acid and of triglycerides with added heparin. In all experiments, the fall in plasma FFA observed during the nicotinic acid infusion or after terminating the TG-heparin infusion was accompanied by an increase in pancreaticoduodenal venous plasma glucagon concentrations corresponding to a true increase in pancreatic glucagon production. These results support the concept of an important role of plasma FFA in controlling the pancreatic glucagon production, at least in dogs.
We express our gratitude to Drs. V. Marks and A. E. Renold for reviewing this manuscript and for helpful criticism, and to Mrs. Cartenstadt and Mrs. Burguet for their expert technical assistance.
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