Abstract
Summary
Adrenal homogenates from intact and castrated male and female rats treated with 1 μg 17β-estradiol iv were tested for ability to convert exogenous DOC to B and 18-OH DOC. Estradiol, which causes a significant increase in hydroxylating capacity in intact female rats, produced no such increase in intact males. Orchiectomized males, however, responded to estradiol with increased ability to hydroxylate. The estradiol response was lost after administration of testosterone to both orchiectomized males and intact females.
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