Abstract
Summary
α-Chloromethyl-2-methyl-5-nitro-1-imidazoleethanol was found to exert marked chemotherapeutic effects against experimentally induced infections of rodents with Endamoeba histolytica, Trichomonas vaginalis, Trichomonas foetus, and against a natural pinworm infection of mice produced by Syphacia obvelata. The substance was also highly active in vitro against anaerobic bacteria but not against facultative or aerobic microorganisms. Except for a slight effect noted in the case of the sarcoma-180 tumor, this 5-nitroimidazole derivative was inactive in all other experimental models tested in vivo including bacteria, fungi, and viruses.
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