Abstract
Summary
Elution curves from both the mucosal and serosal sides of the toad bladder indicate that the sodium transport pool is not a single compartment as previously described in the literature. From 1 to 18 or more minutes there is evidence of two rates of elution from each side of the bladder. From 0 to 1 min there is evidence of a larger quantity of Na being eluted than can be expected from the ECF alone. Arguments are presented that there must be at least five compartments and perhaps as many as eight compartments in the sodium transport pool. Two of these compartments would be Na in the serosal and mucosal inulin spaces.
The authors thank the following: Mr. W. E. Romans and Mr. Alan W. Selway of the medical school's Bioengineering Laboratory for their help in construction of the chambers; Dr. Frank T. Kallus for the design of the mucosal chamber; Mr. John Johnstone and Mrs. Lynn Peterson of the medical school's Scientific Computer Center for their assistance in treatment of the data and in programming the calculations for the computer and to Mr. Robert C. Lipsey for his technical assistance.
Get full access to this article
View all access options for this article.