Abstract
Summary
Using column chromatography with Amberlite XAD-2 and silica gel and countercurrent analysis, a metabolite of naloxone was isolated from human urine. The metabolite was identical to naloxone-3-glucuronide isolated earlier from rabbit urine.
The author is grateful to Drs. Ralph Jacobsen and Harold Blumberg of Endo Laboratories for arranging this study with Drs. Max Fink and Arthur Zaks of the Department of Psychiatry, New York Medical College.
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