Abstract
Summary
Inhibition of antibody formation to heterologous red cells in mice was studied using combinations of cortisone acetate with cyclophosphamide. The two drugs mutually potentiated or antagonized each other. Interaction between the compounds depended on the dose of antigen used for immunization. Pretreatment with cortisone prevented the development of cyclophos-phamide-induced tolerance. It is suggested that in the case of large particulate antigens steroids may block a common pathway leading both to tolerance and to immunity.
The skilled technical assistance of Miss D. Nitsche, Miss U. Petzoldt, and Mrs. T. Glanzmann is gratefully acknowledged.
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