Abstract
Summary
Feeding 5 and 8% excess L-histidine to rabbits caused significantly elevated plasma cholesterol levels. Phospholipid levels were slightly but not significantly elevated. The 5% histidine-supplemented diet produced plasma levels of 20–50 mg/100 ml of histidine. After 17 weeks on diet, no effects on brain cerebrum and cerebellum or liver cholesterol concentrations were found. Brain and liver total lipid and phospholipid and cerebrum galactolipid concentrations were also normal. The effect of excess dietary histidine on lipid components is apparently localized in the circulatory system. The effects noted in rabbits are much less than those previously observed in monkeys.
The technical assistance of Robert Colwell and Robert Jaeger was greatly appreciated.
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