Intestinal Fatty Acid Absorption and Esterification from Luminal Micellar Solutions Containing Deoxycholic Acid 1

Abstract

In summary

These experiments indicate that the toxic effects shown by deoxycholic acid in vitro do not occur in vivo, apparently because transfer of free bile acids into the mesenteric venous system prevents them from reaching dangerous intracellular concentrations. This adds further evidence to the concept that in the blind loop syndrome, unconjugated bile salts are not responsible for the production of steatorrhea, but that decrease in the concentration of conjugated bile salts is the more likely mechanism. The importance of an intact mesenteric circulation in keeping intestinal mucosal free bile acid concentrations from reaching damaging levels is emphasized by these experimental findings.