Abstract
Summary
The Snell-Bagg dwarf mouse was immunologically deficient as shown by severe lymphopenia, decreased agglutinating antibody response to sheep erythrocytes and Brucella antigen, and decreased graft-versus-host reactivity of dwarf spleen cells. The lymphoid organs of the dwarf were small, atrophic, and generally depleted of small lymphocytes. Serum immunoglobulins appeared to be within normal ranges. These findings suggested a selective deficiency of the thymus-dependent lymphoid system of the dwarf, caused by a defective thymotropic pituitary control.
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