Abstract
Summary
Use of either incomplete Freund, alhydrogel, or pertussis vaccine as adjuvants together with rat thyroid extract (RATE) elicited neither antibodies nor thyroiditis when injected into Lewis rats. A complete Freund adjuvant emulsion with RATE gave inconsistent results. Multiple, spaced injections of such an emulsion elicited a severe thyroid reaction. Combination of pertussis vaccine with either incomplete Freund adjuvant or alhydrogel elicited moderate thyroiditis. The most marked thyroiditis was obtained using a combination of CFA and RATE emulsion and a separate injection of pertussis vaccine.
The authors thank Mr. Steven Buck for his expert technical assistance. The pertussis vaccine was donated by Dr. H. B. Devlin of Parke, Davis & Co., Detroit, Mich. The alhydrogel was donated by Dr. Niels Neergaard, Superfos Export Co., Copenhagen, Denmark.
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