Abstract
Summary
Blood levels of PGA and cyano-cobalamin and the urinary excretion of PGA and CF were estimated in scorbutic and paired-fed normal guinea pigs. The urinary excretion of Figlu after administration of histidine also was determined. No significant changes in the blood levels of PGA and cyanocobalamin or in the urinary excretion of PGA, CF, and Figlu were observed in the vitamin C-deficient guinea pigs. The intermediary metabolism of PGA did not seem to be affected as a result of vitamin C deficiency. It seems that in guinea pigs, unlike rats, ascorbic acid has a limited role in the conversion of PGA to CF.
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