Abstract
Summary
In rats with chronic gastric fistulas, secretin had no effect on histamine-stimulated acid secretion. This finding, together with our earlier studies showing that secretin inhibited pentagastrin-stimulated acid secretion but not the increase in histidine decarboxylase activity, cannot be reconciled with the hypothesis that gastrin stimulates acid secretion by releasing histamine.
We are grateful to Dr. Morton I. Grossman for advice and support and to Dr. Lawrence W. Way for help with surgery. This study was supported by Veterans Administration Research Funds. Dr. Johnson was supported by NIH Training Grant No. 5 TO1 AM05470-05. Dr. Johnson's current address is the Department of Physiology and Biophysics, University of Oklahoma Medical Center, Oklahoma City, Oklahoma 73104.
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