Abstract
Summary
Plasminogen activator activity (bilokinase) was demonstrated for the first time in fistula bile of the hamster as well as in the bile of isolated hamster liver. Sodium taurocholate was shown to stimulate the release of bilokinase into bile. Bilokinase in bile is analogous to urokinase in urine, but its role in coagulation homeostasis or in gallstone formation remains to be determined.
Acknowledgment is made of the expert assistance of Mr. Emery Van Hook in preparing the isolated liver system and of Miss Linda L. Livingston in laboratory determinations.
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