Abstract
Summary
Immune globulin synthesis by sensitized lymph nodes, obtained from mice treated with cyclophosphamide, following the application of subcutaneous grafts of sarcoma I was studied by the technique of radi-oimmunoelectrophoresis. There was complete suppression of labeling of 7S γ1 during the homograft reaction as well as almost complete suppression of immunoglobulin synthesis during the first 7 days after grafting. Labeling of 7S γ2 and IgM appeared on the 10th day after the application of the graft. These findings differed from those obtained with untreated tumor-bearing murine hosts.
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