Abstract
Summary
Animals with lymphosarcoma developed progressive anemia, reticulocytosis, and leukocytosis with granulocytosis. In such animals the blood returned to almost normal values after a short treatment with L-asparaginase active serum. The hematocrit was a good index of response to the serum. The ascitic fluid in mice with 6C3HED lymphosarcoma treated with rabbit serum showed no host macrophage response. Marked macrophage infiltration occurred in those mice treated with the L-asparaginase active serum.
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