Abstract
Summary
In dogs with Heidenhain pouches and vagally innervated antral pouches, denervation of the antral pouch produced the following effects on secretion of acid from the Heidenhain pouches: (a) the responses to submaximal doses of exogenous gastrin extract and to histamine were not significantly changed, (b) the response to 2-deoxy-D-glucose, which presumably acts by vagal release of gastrin, was greatly decreased, and (c) the response to bathing the mucosa of the antral pouch with solutions of acetylcholine or glycine was greatly decreased. The results suggest that tonic vagal impulses facilitate the local release of gastrin by acetylcholine and glycine.
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