Abstract
Summary
Dermal allergic reactions in LAF1 mice arising from prior immunizations with dextran or methylated albumin were studied. A plethysmographic technique for measuring mouse paw swelling was developed. At weekly intervals after immunization, mouse paw swelling was assessed to determine the degree of allergic swelling. Because of the large irritative swelling component of dextran itself, methylated albumin was more suitable for studying early and late dermal allergic responses. In all injection schemes but one, for dextran and methylated albumin, mouse paw swelling was lower at 3 weeks than at 2 and 4 weeks after the last immunization.
This work was supported by Atomic Energy Commission Contract No. COO-1632-10 and GM 15956. We are grateful to Dr. A. J. Crowle for reading and commenting on the manuscript.
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