The Effect of Arvin Upon Cardiac Function 1

Abstract

Summary

Arvin, a therapeutic agent which prevents clotting by means of controlled defibrination, was evaluated in five dogs in conjunction with long-term fiberoptic hemodynamic monitoring. Cage-tipped catheters remained free of fibrin clot for more than 18 hr during which time no significant bleeding was noted from cutdown sites. Arvin did not cause any significant changes in left ventricular function, both tension generating and velocity shortening attributes remaining unchanged.