Prostaglandin Inhibition of Innervated Antral Motility in Dogs 1

Abstract

Summary

PGE₁ has been analyzed in terms of its effect on vagally driven gastric motor activity in dogs; profound inhibition of 2-deoxy-d-glucose stimulated motility was observed.

The effect of PGE₁ on serum calcium, potassium, and blood sugar levels has been monitored; no significant change in calcium or potassium during PGE₁ infusion has been noted. Blood sugar, traditionally elevated by 2-deoxy- d-glucose, was not altered from its usual pattern after PGE₁ infusion.

PGE₁ is capable, in doses previously shown to have an inhibitory effect on gastric secretion, to inhibit gastric motility as well. The precise mode of action is speculated upon but remains undisclosed.

A special thanks is given to Miss Catherine Holm for her technical assistance and to Upjohn Company for the PGE₁.