Abstract
Summary
Patchy necrotic lesions of the liver were produced in rabbits by common bile duct ligation. This surgical procedure does not result in any detectable alteration in the kidney. Urinary outflow of tissuelike macromolecules was detected by immunoprecipitation techniques using a specific duck antirabbit tissue serum. The presence of a significant amount of tissue-like macromolecules was demonstrated in the blood stream at the same time. Comparative immunoanalyses of these abnormal plasma and urine proteins showed that a few of them were identical, but that the majority had differing antigenic and electrophoretic patterns. It is probable that the smallest of the molecules (or moieties) originating from the liver had passed through the glomerular membrane, and that the biggest ones had been retained in the blood stream at least for a longer time. This experiment demonstrates that histemia occurs before the histuria resulting from an organic extrarenal lesion.
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