Abstract
Summary
Maternal-fetal transfer of 14C-cyclamate and 14C-cyclohexylamine was studied with the fetus in utero and the amniotic sac intact in rhesus monkeys. Both substances crossed the placenta. With cyclamate, maternal-fetal blood levels of radioactivity were in the approximate ratio of 4:1, suggesting a somewhat limited degree of transmission. By contrast, cyclohexylamine was found to diffuse freely across the primate placenta.
We thank Dr. Robert C. Sonders, Department of Pharmacology, Abbott Laboratories, North Chicago, Illinois, for providing the radioactive-labeled compounds used in the investigation. Capable technical assistance by Pamela Orbaugh, Barbara Bengtson, and Timothy Kling is acknowledged.
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