Abstract
Summary
Although SV40 can replicate well in certain stable cell lines of GMK cells, some of the infected cultures do not support the complementation of the human adenovirus 7. Maximum complementation occurred only in the primary cells although consistent complementation at a lower level was detected in CV-1 cells. No complementation occurred in Vero cells and little, if any, was detected in BSC-1 cells. Therefore, the host cell has a role in determining the interaction of these two viruses and conditions other than those necessary for the efficient replication of SV40 must be present for the complementation of the human adenoviruses in simian cells.
We thank Beverly Poole for helping with these studies.
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