Abstract
Summary
Extracts of the amniotic and chorionic membranes contain a factor which blocks the action of interferon. The anti-interferon effect can be induced when the antiviral state mediated by interferon is already established. The tissue antagonist of interferon (TAI) is present in the acidosoluble fraction after precipitation with 5% trichloroacetic acid. It does not dialyze or sediment after ultracentrifugation. It is resistant to proteases, to heat, and to low pH. Although the biological role of this substance is unknown, it is postulated that it may contribute to terminate an antiviral state in the tissue and restore cellular receptivity to viruses.
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