Abstract
Summary
The aortic cholesterol concentrations of rats fed a chow diet containing CPIB (0.25%) for 10 days subsequent to feeding on a high cholesterol (1%) for 10 days subsequent to feeding on a high cholesterol (1%)-cholic acid (0.5%) diet for 2 weeks were significantly lower than those of rats fed the chow diet alone on the same schedule. This finding was repeated in rats fed a high sucrose (63%) diet with or without CPIB (0.25%) for 2 weeks. In the first instance, the reduction in aortic cholesterol levels was related temporally to a reduction in serum cholesterol concentrations in the CPIB-fed rats. This effect of CPIB may be related to a potential antiatherogenic property of the drug.
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