Abstract
Summary
Cations stabilized poliovirus against inactivation by urea (0.5-4.5 M) and heat (45°) but to sensitize it to inactivation by guanidine, indicating that urea and heat affect the same structure on the virion which is different from those affected by guanidine. Choline, methionine, betaine, and even guanidine had similar effects as cations. However, certain low concentrations of choline and methionine were also able to partially prevent guanidine inactivation. The action of these compounds on the reactivity of po-liovirion is discussed in terms of induced conformational changes of the viral capsid protein.
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