Abstract
Summary
Pretreatment of hypophysectomized rats with growth hormone 3.5 hr before sacrifice significantly increased free fatty acid (FFA) production by epididymal fat incubated in vitro in the presence of epinephrine. No change in glycerol production in response to epinephrine was seen even when rats were pretreated with growth hormone for 3 days. In replicate tissues from the same animals, pretreatment with growth hormone significantly increased glycerol production in response to theophylline. It is suggested that growth hormone may exert a small effect on the basal activity of adenyl cyclase.
The superb technical assistance rendered by Mrs. Rosalie Snyder and Mrs. Eleanor Herzog is gratefully acknowledged.
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