Hypoferremia Produced by Plasma from Endotoxin-Treated Rats

Abstract

Summary

After intravenous injection of endotoxin in the rat, a hypoferremia-producing factor remained in the plasma for 5-6 hr. This factor was different from endotoxin incubated in vitro with rat plasma. Endotoxin, however, was still present, suggesting the in vivo formation of a protein—endotoxin complex. The possibility of an intermediate being involved in the production of hypoferremia in the rat after endotoxin injection was discussed.