Abstract
Summary
The growth of ultravioletirradiated herpes simplex virus was studied in cultures of skin fibroblasts from a patient with xeroderma pigmentosum and compared with growth in WI-38 cells, skin fibroblasts from people with no evidence of xeroderma pigmentosum and in HeLa cells. The irradiated virus grows less efficiently in the xeroderma pigmentosum cells than it does in the other cell lines examined, suggesting that mechanisms for repair of the UV-damaged viral DNA may be deficient in the xeroderma pigmentosum cells. This is consistent with previous observations of others that repair mechanisms for UV-damaged cellular DNA may be defective in skin fibroblasts and leukocytes from patients with xeroderma pigmentosum.
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