Abstract
Summary
The limited attachment and replication of coxsackievirus A13 by cultures of primary fetal mouse cells was demonstrated for the first time. These results, taken together with the findings that CPE and interferon were undetectable in infected cultures support the hypothesis that a small number of cells in the population were susceptible to A13 virus infection. Efforts are now being made to determine the identity of the susceptible cell and to develop methods for increasing the proportion of susceptible cells in primary fetal mouse cultures.
This investigation was supported by Public Health Research grants AI-05769 and AI-03771 from the National Institute of Allergy and Infectious Diseases.
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