Abstract
Summary
A large dose of methylprednisolone (100 mg/kg) given to mice 1 hr before challenge with sparsomycin and bacterial endotoxin significantly prolonged their survival time. The same dose of methylprednisolone given 1 hr before challenge with pactamycin and bacterial endotoxin protected mice against the synergistic toxicity. Phenylbutazone (120 mg/kg) and chlorpheniramine (4 mg/kg) failed to diminish the toxicity of the pactamycin-endotoxin synergy.
Sparsomycin, pactamycin, phenylbutazone, and 6α-methylprednisolone (Medrol) were generously supplied by Dr. G. S. Fonken, The Upjohn Company, Kalamazoo, Michigan.
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