Abstract
Summary
During 5 ATA oxygen exposures: The GSH was the best single compound for protecting against oxygen toxicity. This appears to be a combined SH protection and metabolite (glutamate → GABA → succinate) protection. The SH group protection, as evidenced by the cysteine experiments, was not as effective as the metabolites: succinate, glutamate, and GABA. The acid-base buffer Tris was less effective than the SH group protectors, or GABA, glutamate, or succinate. Glucose and malate gave no protection against oxygen toxicity.
We thank Marvin and Julia Nunn for valuable technical assistance.
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