Abstract
Summary
Rabbit immune serum acting with guinea pig complement causes Ehrlich tumor cells to lose their intracellular ATP. Determining the residual ATP in the cells by the luciferin-luciferase test after exposure to the dilutions of the antitumor serum gives a measurement of the antitumor properties of the serum. It is suggested that this approach could be used in other immunological measurements involving cytolysis of cells.
Financial support for this work came from funds made available to the University of Michigan by the Legislature of the State of Michigan for cancer research.
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