Abstract
Summary
Using the reagent 5,-5′-dithiobis(2-nitrobenzoic acid), a sulfhy-dryl-disulfide (SH-SS) interchange reaction was observed and characterized in serum of normal rats and rats with adjuvant-induced arthritis. The SH-SS interchange reaction was severely retarded in the latter group of animals but could be restored essentially to normal by appropriate therapy with steroidal or nonsteroidal anti-inflammatory agents. The defect in SH group availability was detectable as early as 4 days after adjuvant injection and well before the appearance of gross arthritic lesions (days 10–15). The abnormal serum SH-SS interchange reaction was specific for rats with adjuvant arthritis and did not appear in adjuvant-treated rats which failed to develop arthritis or in a variety of other experimentally induced inflammatory states.
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