Abstract
Summary
Dopamine (0.1 and 1 mg/ mouse) inhibited DNA synthesis in mouse spleen. This effect was reversible and was not related to the availability of fewer cells in S phase because the labeling index of spleen cells was similar in both dopamine-treated and control animals. Dopamine produced no change in the rate of synthesis of spleen protein.
Dopamine (50 μg/ml) completely inhibited the growth of HeLa Chessen cell populations in vitro. Dopamine at a low dose (5 to 25 μg/ml) produced only a partial inhibition of the growth. Both the onset of division delay and the time required for recovery are dose-dependent in this dose range. Dopamine also reduced the incorporation of 3H-thymidine into newly synthesized DNA, whereas the percentage of cells synthesizing DNA remained unchanged.
Get full access to this article
View all access options for this article.