Mouse Mammary Carcinogenesis by Ethyl and Butyl Carbamates 1

Abstract

Summary

Experiments examining the effect of ethyl carbamate and butyl carbamate on mammary carcinogenesis are reported. Virgin female C₃H mice receiving ethyl carbamate or butyl carbamate showed a higher incidence of tumors than the controls. The action of ethyl carbamate was the same when given in massive or fractionated dose but a massive dose shortened the latent period of tumor development. Simultaneous administration of ethyl carbamate and butyl carbamate had a summational effect. Administration of croton oil to animals receiving ethyl carbamate did not provoke the appearance of skin tumors. A higher number of metastases was observed in animals bearing breast tumors when ethyl carbamate or butyl carbamate was administered.