Abstract
Summary
An isolated perfused rabbit liver model was utilized to study the hepatic uptake of 51Cr-endotoxin. Perfusates containing 5% normal rabbit serum produced relatively low uptake of endotoxin compared to the striking enhancement of uptake caused by 5% serum from endotoxin-tolerant rabbits. The serum factor (or factors) responsible for hepatic uptake of endotoxin was heat-stable. There was not a close correlation between the “O” agglutinin titer of serum samples and their effect on hepatic uptake. There was no significant difference between endotoxin uptake recorded in perfused livers from normal rabbits and those from endotoxin-tolerant rabbits.
We wish to thank Miss Laura Treanor and Mrs. Sheila Timmons for their valuable assistance in the performance of these studies.
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