Effect of N -γ-Phenylpropyl- N -benzyloxy Acetamide (W-1372) and of Clofibrate on the Lipids of Normal and Hypercholesteremia Rats

Abstract

Summary

N-γ-Phenylpropyl-N-benzyloxy acetamide (W-1372) and clofibrate were given to weanling rats in the diet for 2 weeks. The hypocholesteremic and other effects of the drugs differed greatly depending on the kind of diet which was provided. Qofibrate reduced serum cholesterol of animals on the usual, normocholesteremic diet, but had much less effect in animals on a hypercholesteremic, high fat diet. W-1372, in contrast, was much more effective in lowering blood cholesterol levels in animals fed a high fat diet. The two drugs also produced different effects on liver cholesterol, liver triglycerides, the serum liver cholesterol pool and the protein content of the livers. Both drugs produced liver enlargement but did not affect plasma SGOT, SGPT, and alkaline phosphatase. These findings suggest that different mechanisms are involved in the hypocholesteremic action of these compounds.